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Progesterone is a reproductive sex hormone that peaks during the luteal phase of menstrual cycles. This surge of progesterone thickens uterine lining to prepare for conception; if no conception takes place, progesterone levels drop as corpus luteum breaks down and its effectiveness diminishes.
Women experiencing amenorrhea may take medications that mimic natural progesterone hormone to relaunch the menstrual cycle and start bleeding again.
Can Progesterone Cause Weight Gain?

Does Progesterone Trigger Weight Gain?
Progesterone’s impact on weight is tied to its interaction with estrogen. Though not a direct cause, hormone imbalance can lead to unexplained gain. Excessive progesterone can indeed drive weight increase, not loss.
It mitigates effects of other weight-affecting hormones. Progesterone and estrogen collaborate for balanced, fertile weight control.
Why Progesterone May Lead to Gain:
– Balanced levels aid metabolism.
– Progesterone and insulin resistance link; excess or deficiency disrupts blood sugar control.
– Menopause shifts responses to diets due to hormone flux.
Progesterone’s influence spans weight gain and loss based on lifestyle, hormone levels, and health. Low progesterone allows erratic estrogen, fostering gain; high progesterone can prompt swift loss.
In essence, while not a direct cause, hormone imbalance underpins unexplained gain. Progesterone’s role blends with estrogen’s, pivotal for balanced metabolism.
Is Weight Gain a Side Effect of Progesterone Medications or Supplements?
Progesterone doesn’t directly lead to weight gain; however, when estrogen levels are elevated and progesterone is low it may increase appetite as progesterone acts to neutralise estrogen’s effects on your uterus and appetite.
Progesterone levels increase substantially during gestation to assist with preparation of the uterus for egg implant and support fetus growth.
As your natural progesterone levels decline during perimenopause, and as your doctor prescribes you with progestin as a replacement treatment option to take on a regular basis (usually as a capsule), progestin may become part of your medication regimen – it often alternates 10 days of treatment followed by 16 days off-treatment – so if you suffer from kidney or heart conditions as this medication could potentially increase fluid retention. It should always be discussed beforehand with your healthcare provider.
What Can I Do to Prevent Weight Gain?
Women tend to gain weight during perimenopause as their natural hormone levels shift, often leading to weight gain. Women may choose to treat these changes with medication like progesterone or progestin; there are various kinds of these pills; in general though it’s best to steer clear from synthetic forms as these tend to be metabolized differently by your body and produce higher amounts of pregnanediol (an estrogen metabolite).
Weight fluctuations do not provide a clear indicator of hormone health; any sudden shifts in weight could indicate something is amiss in both your hormones and body.
Progesterone is an ovarian hormone that prepares the endometrium for pregnancy by thickening its lining. When pregnant, progesterone helps fertilized eggs implant and grow into viable foetuses.
Progesterone may also help alleviate symptoms associated with premenstrual syndrome. For optimal effectiveness, progesterone should be taken in either cream form, vaginal gel form or via prescription pill such as Prometrium.

How Does Progesterone Affect Appetite and Metabolism
Progesterone influences metabolism, blood sugar, and insulin, potentially shaping appetite and weight. The interplay of progesterone and estrogen impacts appetite and metabolism. Estrogen curbs food intake, while progesterone and testosterone can trigger hunger.
During the initial menstrual phase, estrogen restrains eating, potentially lowering hunger. Post-ovulation, progesterone surges, escalating metabolism and enhancing appetite. Additionally, progesterone may heighten hunger through activating ghrelin, a pivotal hunger-related hormone.
In summary, progesterone affects appetite and metabolism, alongside the interplay of progesterone and estrogen. Estrogen restrains eating, whereas progesterone and testosterone might boost hunger.
The initial menstrual phase sees estrogen moderating food intake, potentially minimizing hunger. Post-ovulation, progesterone surges, quickening metabolism, and boosting appetite. Furthermore, progesterone may intensify hunger by activating ghrelin, a crucial hunger-related hormone.
What Are the Other Factors That Can Cause Weight Gain Besides Progesterone
Beyond progesterone, various factors contribute to weight gain. Consider these influences:
- Hormonal Imbalances: Weight gain results from imbalances like low progesterone, high estrogen, thyroid irregularities.
- Pregnancy: Commonly, pregnancy prompts unintentional weight gain as the baby develops.
- Menopause: Hormonal shifts in menopause lead to abdominal, hip weight gain. Middle-age hormonal changes slow metabolism, causing weight gain.
- Polycystic Ovarian Syndrome (PCOS): Hormonal imbalances in PCOS result in weight gain.
- Unhealthy Diet: Weight gain links to diets high in processed foods, sugar, unhealthy fats.
- Sedentary Lifestyle: Weight gain associates with lack of physical activity.
- Medications: Antidepressants, antipsychotics, steroids can cause weight gain as side effects.
To sum up, weight gain is influenced by factors beyond progesterone, encompassing hormonal imbalances, pregnancy, menopause, PCOS, unhealthy diet, sedentary lifestyle, medications.
Can Progesterone Supplements Help With Weight Loss
Some evidence suggests progesterone supplements might aid weight loss. Ways it could help include:
- Insulin Level Drop: Raised progesterone may lower insulin, curbing sugar cravings, aiding weight loss.
- Hormonal Balance: Balanced hormones foster moderation in eating, aiding weight loss. Progesterone helps balance hormones, regulates appetite.
- Thyroid Function Boost: Progesterone might enhance thyroid function, boosting metabolism and weight loss.
- Inflammation Reduction: Progesterone’s anti-inflammatory role can regulate appetite, aiding weight loss.
- Natural Sleep Aid: Progesterone aids sleep, vital for weight control as sleep influences appetite-regulating hormone leptin.
Note: Progesterone doesn’t directly cause weight loss. It reduces impact of other hormones related to weight gain. Healthy progesterone levels are vital; excess or deficiency can disrupt blood sugar control, cause weight gain.
To sum up, while progesterone supplements might aid weight loss via insulin reduction, hormonal balance, thyroid function boost, inflammation reduction, and sleep aid, healthy progesterone levels are key, and progesterone doesn’t directly induce weight loss.

Conclusion
Progesterone may not directly cause weight gain, but its side effects may make you hungry and tired – leading you to overeat or skip exercise altogether.
Pregnancy requires high levels of progesterone to sustain fertilized eggs and their developing embryo. Progesterone thickens the uterine lining, essential for pregnancy; once placenta formation takes place, its blood vessels provide essential nourishment to support an healthy fetus, according to the National Library of Medicine.
Higher levels of progesterone can also cause unexplained weight gain and bloating when taken outside pregnancy, so if this happens to you it may be wise to speak to your physician and consider switching forms of hormone therapy such as progesterone injections (Prometrium).
You can administer these injections yourself at home; just be sure that a health care provider or sharps container has provided training. You must follow all instructions from your healthcare provider regarding how often and how much should be administered.