Both Xopenex and albuterol can effectively open your airways during an asthma attack, yet each has their own set of specific benefits. There are some key distinctions between the two medications.
Xopenex and Xopenex HFA may interact with other medications and supplements, possibly altering how effectively the medicine works or increasing side effects. For more information regarding interactions, consult your healthcare provider or pharmacist.
Xopenex Vs Albuterol – What’s the Difference?

When it comes to treating bronchospasm, medications like albuterol and levalbuterol play a crucial role. While they belong to the same class of inhaled beta-2 agonists and are used for similar conditions, there are notable differences between these two medications.
Here’s what you need to know:
Albuterol: The Standard Choice for Acute Bronchospasm
- Composition: Albuterol consists of equal parts of a racemic mixture of R- and S-enantiomers.
- Widely prescribed: Albuterol is the most commonly prescribed inhaled beta-2 agonist and is considered the drug of choice for reversing acute bronchospasm.
- Administration: It is typically used as a rescue inhaler or through a nebulizer to provide quick relief.
Levalbuterol: A Selective Alternative
- Composition: Levalbuterol contains only the active R-enantiomer.
- Selectivity: It is classified as a moderately selective, short-acting beta-2-receptor agonist (SABA).
- Usage: Levalbuterol shares many of the same uses as albuterol, including its effectiveness as a rescue inhaler or nebulizer and its ability to alleviate COPD symptoms.
Comparing the Effects and Clinical Considerations
While both racemic albuterol and levalbuterol demonstrate positive effects in treating asthma, such as enhancing the action of corticosteroids and reducing inflammatory mediators, clinical studies do not indicate a clear superiority of levalbuterol over racemic albuterol.
In fact, some studies suggest that (S)-albuterol, a component of racemic albuterol, remains in the bloodstream for a longer duration than levalbuterol, potentially leading to paradoxical effects.
However, there is evidence supporting the use of levalbuterol over albuterol in patients with tachyarrhythmia, a condition characterized by irregular heart rhythm. Additionally, Xopenex (levalbuterol) inhaler is reported to be more expensive than albuterol inhaler according to Goodrx.com.
Consultation with a Healthcare Provider is Key
To determine the most suitable medication for an individual’s specific needs, it is crucial to consult with a healthcare provider.
While both albuterol and levalbuterol are effective in treating bronchospasm, the choice between them may depend on factors such as the patient’s medical history, existing conditions, and any potential drug interactions.
By working closely with a healthcare provider, the best course of treatment can be determined for optimal results.
Other Considerations on Xopenex or albuterol

Efficacy
Xopenex and albuterol are bronchodilators used to treat respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). Both drugs work by relaxing the muscles that line your airways of your lungs; however, there may be differences between them that impact how they work as well as possible side effects that arise.
Xopenex contains the R-isomer while albuterol contains S-isomer of this drug; studies indicate that R-isomer may have more of an impact on bronchospasm for patients with asthma than S-isomer, leading to greater effectiveness at relieving symptoms in adults and children alike, albeit the difference is often only marginal.
Side effects of Xopenex may include nervousness, shaking (tremor), dizziness, headache, dry mouth/throat sore throat coughing runny or stuffy nose and chest pain.
Individuals taking Xopenex should refrain from drinking alcohol or taking other medications that interact with it as this could increase the risk of serious side effects such as changes in heart rhythm or chest pain and feelings of fluttering in their chests.
Both Xopenex and albuterol are short-acting beta-agonists that should only be taken when needed to treat an asthma attack. Regular dosing could lead to dependence and may not effectively treat sudden breathing difficulties. It is wise to consult your physician if you find yourself needing more frequent rescue inhaler use than recommended.
Safety
Both Xopenex and albuterol can help open airways to treat respiratory conditions like asthma or chronic obstructive pulmonary disease (COPD), but there may be differences between them that affect how each is taken, possible side effects experienced and whether or not they’re suitable for your condition.
Albuterol can safely be taken by children aged under 12. However, Xopenex should not be given to those under 12 due to potential side effects that include rapid heart rates which could prove harmful; contrary to this recommendation from experts.
Studies are ongoing regarding whether or not taking Xopenex during pregnancy has any impact on its effects on developing fetuses.
Xopenex HFA comes as both inhaled liquid and tablets and should only ever be taken as prescribed by your healthcare provider. You should never exceed the dose prescribed; please discuss dietary and alcohol consumption with them to make sure this medication is suitable for you.
Side effects

Xopenex and albuterol are both effective bronchodilators that can help open up airways in the lungs, making breathing easier. Both drugs may be taken as rescue medications but should be part of a comprehensive treatment plan with other corticosteroids to avoid flare-ups and keep symptoms under control.
Both Xopenex and albuterol are short-acting beta agonists used to treat bronchospasm caused by reversible obstructive airway disease, including asthma. Both options come as powders intended for inhalation through nebulizers or aerosol spray (Xopenex HFA), respectively, for easy administration into the lungs.
Studies have revealed that both medications increase FEV1 by 35-40% within 30 minutes when taken orally or via nebulizer.
Asthmatic patients may benefit from taking levalbuterol (the active ingredient found in Xopenex and Xopenex HFA), a less potency version of albuterol. Both medications have been proven to significantly improve symptoms while decreasing exacerbations when taken as directed.
For some people however, other therapies might work better, including taking an alternative treatment like levalbuterol which is used in both medications.
Both Xopenex and albuterol may cause side effects, including diarrhea, vomiting, headache and dizziness.
They may also increase heart rate and blood pressure. It’s best to consult your physician if experiencing heart or blood pressure problems; otherwise do not use either medication without consulting first with their healthcare providers first.
Furthermore, people allergic to levalbuterol or albuterol should not take Xopenex HFA products.
Suitability

Xopenex and albuterol can both be effective medications for treating respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD), but their individual suitability depends on several factors, including age, severity of condition and method of administration.
For instance, Xopenex should not be given to children under four while albuterol may be better-suited.
Patients suffering from certain underlying medical issues may not be able to tolerate one medication over the other. For instance, those allergic to sulfites used as preservatives in albuterol might prefer Xopenex instead as it does not contain these preservatives.
Choice between Xopenex and albuterol also depends on a patient’s insurance coverage for either medication. Prior authorization may be needed from some insurance providers for Xopenex treatment; to minimize costs further contact your insurer for more details.
For Xopenex it’s also essential that it is used regularly and replenished before running out completely – to do this successfully call your pharmacy and arrange an order before this happens.